Prevalence of microvascular complications in patients with NAFLD
DOI:
https://doi.org/10.62992/kykyda89Keywords:
Microvascular complications, Non-alcoholic fatty liver disease, Type 2 diabetes patientsAbstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder that is strongly associated with Type 2 Diabetes Mellitus (T2DM).
Objective: This study was designed to determine the prevalence of NAFLD among T2DM patients and to evaluate whether there is an association between NAFLD and diabetic microvascular complications.
Methods: This was a hospital-based cross-sectional descriptive study conducted during one year from January 2018 to December 2018. A total of 107 type 2 diabetes patients were submitted to clinical and laboratory evaluation and abdominal ultrasonography for NAFLD detection. Statistical analysis such as the chi-square test, and univariate and multivariate logistic regression was used in this study.
Results: Out of 107 type 2 diabetic patients, 54.2% patients had NAFLD whereas 45.8% had no fatty liver on ultrasonography. NAFLD group had a significantly higher prevalence of retinopathy (41.4% versus 20.4%, P-value 0.02), neuropathy (58.6% versus 14.3%, P-value <0.001), and nephropathy (67.2% versus 49.0%, P-value <0.05). Moreover, after logistic regression was done, diabetes patients with NAFLD had 8.88 times the risk of neuropathy than those without NAFLD (OR= 8.88 95% CI: 2.95-26.74, P-value <0.001).
Conclusion: The prevalence of NAFLD is higher in type 2 diabetes patients. This study also reported the prevalence of microvascular complications was higher in patients with NAFLD. Therefore, ultrasound examination of the liver for NAFLD can be used as an early marker of diabetes and its complications.
References
Amos AF, McCarty DJ, Zimmet PJDm. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabetic medicine. 1997;14(S5):S7-S85.
Wild S, Bchir MB, Roglic G, Green A, Sci M, Sicree R, et al. Global Prevalence of Diabetes Estimates for the year 2000 and projections for 2030. 2004.
Latt TS, Zaw KK, Ko KJYMoH, WHO,, Foundation WD. Report on National Survey of Diabetes Mellitus and Risk factors for Non-communicable Diseases in Myanmar. 2014.
Luxmi S, Sattar RA, Ara JJJ. Association of non-alcoholic fatty liver with type 2 diabetes mellitus. Jlumhs. 2008;9:188-93.
Cusi K. Nonalcoholic Fatty Liver Disease in Diabetes: A Call to Action. Diabetes Spectrum. 2024;37(1):5-7.
Deravi N, Dehghani Firouzabadi F, Moosaie F, Asadigandomani H, Arab Bafrani M, Yoosefi N, et al. Non-alcoholic fatty liver disease and incidence of microvascular complications of diabetes in patients with type 2 diabetes: a prospective cohort study. Frontiers in Endocrinology. 2023;14:1147458.
Afarideh M, Aryan Z, Ghajar A, Ganji M, Ghaemi F, Saadat M, et al. Association of non-alcoholic fatty liver disease with microvascular complications of type 2 diabetes. Primary Care Diabetes. 2019;13(6):505-14.
Myat T. A study of the clinical and biochemical aspect of non-alcoholic fatty liver disease in diabetic patients. Yangon: University of Medicine 1, Yangon; 2015.
Lv W-S, Sun R-X, Gao Y-Y, Wen J-P, Pan R-F, Li L, et al. Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes. World Journal of Gastroenterology. 2013;19(20):3134.
Suresh V, Guptha N, Bhargavi E. Association of micro and macrovascular complications with fatty liver in patients with type 2 diabetes mellitus. 2014.
Somalwar A, Raut A. Study of association of non alcoholic fatty liver disease (NAFLD) with micro and macrovascular complications of type 2 diabetes mellitus (T2DM). International Journal of Research in Medical Sciences. 2014;2:493.
Targher GA, Guido. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. J Atherosclerosis. 2007;191(2):235-40.
Williamson RM, Price JF, Glancy S, Perry E, Nee LD, Hayes PC, et al. Prevalence of and risk factors for hepatic steatosis and nonalcoholic Fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes Study Diabetes care. 2011;34(5):1139-44.
Song D, Li C, Wang Z, Zhao Y, Shen B, Zhao W. Association of non-alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta-analysis of observational studies. Journal of Diabetes Investigation. 2021;12(8):1471-9.
Greco C, Nascimbeni F, Carubbi F, Andreone P, Simoni M, Santi D. Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine [Internet]. 2021; 10(19).
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2025 International Journal of Public Health Asia Pacific
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
International Journal of Public Health Asia Pacific (IJPHAP) is licensed under a Creative Commons Attribution-Non-Commercial-No Derivatives 4.0 international (CC BY-NC-ND 4.0) license, unless otherwise stated. Please read our Policies page for more information on Open Access, copyright, and permissions.
